Canman Lab Publications

Dias Maia Henriques AM, Davies TR, Dmitrieff S, Minc N, Canman JC, Dumont J, Maton G. Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation. J Cell Biol. 2026 Jan 5;225(1):e202505038. doi: 10.1083/jcb.202505038. Epub 2025 Oct 22. PMID: 41124275

El Mossadeq L, Bellutti L, Le Borgne R, Canman JC, Pintard L, Verbavatz JM, Askjaer P, Dumont J. An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes. J Cell Biol. 2025 Mar 3;224(3):e202403125. doi: 10.1083/jcb.202403125. Epub 2024 Dec 26. PMID: 39724138

Connors CQ, Martin SL, Dumont J, Shirasu-Hiza M, Canman JC. Cell type-specific regulation by different cytokinetic pathways in the early embryo. MicroPubl Biol. 2024 Oct 22;2024:10.17912/micropub.biology.001316. doi: 10.17912/micropub.biology.001316. eCollection 2024. PMID: 39502424

Bellutti L, Macaisne N, El Mossadeq L, Ganeswaran T, Canman JC, Dumont J. Regulation of outer kinetochore assembly during meiosis I and II by CENP-A and KNL-2/M18BP1 in C. elegans oocytes. Curr Biol. 2024 Nov 4;34(21):4853-4868.e6. doi: 10.1016/j.cub.2024.09.004. Epub 2024 Sep 30. PMID: 39353426

Perrier A, Guiglielmoni N, Naquin D, Gorrichon K, Thermes C, Lameiras S, Dammermann A, Schiffer PH, Brunstein M, Canman JC, Dumont J. Maternal inheritance of functional centrioles in two parthenogenetic nematodes. Nat Commun. 2024 Jul 18;15(1):6042. doi: 10.1038/s41467-024-50427-5. PMID: 39025889

Connors CQ, Mauro MS, Wiles JT, Countryman AD, Martin SL, Lacroix B, Shirasu-Hiza M, Dumont J, Kasza KE, Davies TR, Canman JC. Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. Mol Biol Cell. 2024 Jul 1;35(7):ar94. doi: 10.1091/mbc.E24-02-0096-T. Epub 2024 May 2. PMID: 38696255

Tener SJ, Lin Z, Park SJ, Oraedu K, Ulgherait M, Van Beek E, Martínez-Muñiz A, Pantalia M, Gatto JA, Volpi J, Stavropoulos N, Ja WW, Canman JC, Shirasu-Hiza M. Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder. Sci Rep. 2024 Jan 17;14(1):1541. doi: 10.1038/s41598-024-51657-9. PMID: 38233464

Gareil N, Gervais A, Macaisne N, Chevreux G, Canman JC, Andreani J, Dumont J. An unconventional TOG domain is required for CLASP localization. Curr Biol. 2023 Aug 21;33(16):3522-3528.e7. doi: 10.1016/j.cub.2023.07.009. Epub 2023 Jul 28. PMID: 37516114

Laras Pitayu-Nugroho, Mélanie Aubry, Kimberley Laband, Hélène Geoffroy, Thadshagine Ganeswaran, Audi Primadhanty, Julie C Canman, Julien Dumont. Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes. Nat Commun. 2023 Jul 7;14(1):4032. doi: 10.1038/s41467-023-39702-z. PMID: 37419936

Pantalia M, Lin Z, Tener SJ, Qiao B, Tang G, Ulgherait M, O'Connor R, Delventhal R, Volpi J, Syed S, Itzhak N, Canman JC, Fernández MP, Shirasu-Hiza M. Drosophila mutants lacking the glial neurotransmitter-modifying enzyme Ebony exhibit low neurotransmitter levels and altered behavior. Sci Rep. 2023 Jun 27;13(1):10411. doi: 10.1038/s41598-023-36558-7. PMID: 37369755

Macaisne N, Bellutti L, Laband K, Edwards F, Pitayu-Nugroho L, Gervais A, Ganeswaran T, Geoffroy H, Maton G, Canman JC, Lacroix B, Dumont J. Synergistic stabilization of microtubules by BUB-1, HCP-1 and CLS-2 controls microtubule pausing and meiotic spindle assembly. Elife. 2023 Feb 17;12:e82579. doi: 10.7554/eLife.82579.

Aber ER*, Griffey CJ*, Davies T, Li AM, Yang YJ, Croce KR, Goldman JE, Grutzendler J, Canman JC, Yamamoto A. Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. Cell Rep. 2022 Oct 18;41(3):111480. doi: 10.1016/j.celrep.2022.111480. *Authors contributed equally.

Hirsch SM, Edwards F, Shirasu-Hiza M, Dumont J, Canman JC. Functional midbody assembly in the absence of a central spindle. J Cell Biol. 2022 Mar 7;221(3):e202011085. doi: 10.1083/jcb.202011085.

Ulgherait M, Midoun AM, Park SJ, Gatto JA, Tener SJ, Siewert J, Klickstein N, Canman JC, Ja WW, Shirasu-Hiza M. Circadian autophagy drives iTRF-mediated longevity. Nature. 2021 Oct;598(7880):353-358. doi: 10.1038/s41586-021-03934-0.

Ulgherait M, Chen A, McAllister SF, Kim HX, Delventhal R, Wayne CR, Garcia CJ, Recinos Y, Oliva M, Canman JC, Picard M, Owusu-Ansah E, Shirasu-Hiza M. Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun. 2020 Apr 21;11(1):1927. doi: 10.1038/s41467-020-15617-x.

Delventhal R*, O'Connor RM*, Pantalia MM*, Ulgherait M, Kim HX, Basturk MK, Canman JC, Shirasu-Hiza M. Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption. Elife. 2019 Oct 15;8:e48308. doi: 10.7554/eLife.48308. *Authors contributed equally.

S.M. Hirsch*, S. Sundaramoorthy*, T. Davies, Y. Zhuravlev, J.C. Waters, M. Shirasu-Hiza, J. Dumont & J.C. Canman. 2018. FLIRT: fast local infrared thermogenetics for subcellular control of protein function. Nature Methods. 15: 921-3. doi: 10.1038/s41592-018-0168-y. [PDF] *Authors contributed equally.

J. Wang, E. Batourina, K.Schneider, S. Souza, T. Swayne, C. Liu, C.D. George, T. Tate, H. Dan, G. Wiessner, Y. Zhuravlev, J.C. Canman, I.U. Mysorekar, C.L. Mendelsohn. 2018. Polyploid superficial cells that maintain the urothelial barrier are produced via incomplete cytokinesis and endoreplication. Cell Reports. 25(2): 464-77. doi: 10.1016/j.celrep.2018.09.042 [PDF]

F. Edwards, G. Maton, N. Gareil, J.C. Canman, and J. Dumont. 2018. BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore. eLife. 7:e40690. [PDF]

T. Davies, H.X. Kim, N. Romano Spica, B.J. Lesea-Pringle, J. Dumont, M. Shirasu-Hiza, and J.C.  Canman. 2018. Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. eLife. 7:  e36204. doi:  10.7554/eLife.36204. [PDF]

V.M. Hill, R.M. O’Connor, G.B. Sissoko, I.S. Irobunda, S. Leong, J.C. Canman, N. Stavropoulos, M. Shirasu-Hiza. 2018. A bidirectional relationship between sleep and oxidative stress in Drosophila. PLoS Biology. 16(7): e2005206. doi: 10.1371/journal.pbio.2005206 [PDF]

B. Lacroix, G. Letort, L. Pitayu, J. Sallé, M. Stefanutti, G. Maton, A.M. Ladouceur, J.C. Canman, P.S. Maddox, A.S. Maddox, N. Minc, F. Nédélec, J. Dumont. 2018. Microtubule dynamics scale with cell size to set spindle length and assembly timing. Developmental Cell. 45(4): 496-511. doi: 10.1016/j.devcel.2018.04.022 [PDF]

K. Laband, B. Lacroix, F. Edwards, J.C. Canman, J. Dumont. 2018. Chapter 11 - Live imaging of C. elegans oocytes and early embryos, In: Helder Maiato, Melina Schuh, Editors, Methods in Cell Biology, Academic Press, Volume 145, pages 217-236. doi: 10.1016/bs.mcb.2018.03.025 [PDF]

J.C. Canman, C. Cabernard. 2018. Mechanics of cell division and cytokinesis. Molecular Biology of the Cell. 29(6): 685-686. doi: 10.1091/mbc.E17-11-0671 [PDF]

K. Laband, R. Le Borgne, M. Stefanutti, J.C. Canman, J.M. Verbavatz, and J. Dumont. 2017.  Chromosome segregation occurs by microtubule pushing in oocytes. Nature Communications. 8(1):1499. doi: 10.1038/s41467-017-01539-8. [PDF]

E. Gigant, M. Stefanutti, K. Leband, A. Gluszek-Kustusz, F. Edwards, B. Lacroix, G. Maton, J.C. Canman, J.P.I. Welburn, and J. Dumont. 2017. Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes. Development. 144:1674-1686. doi: 10.1242/dev.147504 [PDF]

Y. Zhuravlev, S. Hirsch, S.N. Jordan, M. Shirasu-Hiza, J. Dumont, and J.C. Canman. 2017. CYK-4 regulates Rac, but not Rho, during cytokinesis. Molecular Biology of the Cell. 28(9):1258-1271. doi:10.1091/mbc.E17-01-0020. [PDF]

S. Sundaramoorthy, A.G. Badaracco, S.M. Hirsch, J.H. Park, T. Davies, J. Dumont, M.M. Shirasu-Hiza, A.C. Kummel, J.C. Canman. 2017. Low Efficiency Upconversion Nanoparticles for High-Resolution Coalignment of Near-Infrared and Visible Light Paths on a Light Microscope. ACS Applied Materials and Interfaces. 9(9):7929-7940. doi: 10.1021/acsami.6b15322 [PDF]

R.M. O’Connor*, E.F. Stone*, C.R. Wayne, E.V. Marcinkevicius, M. Ulgherait, R. Delventhal, M.M. Pantalia, V.M. Hill, C.G. Zhou, S. McAllister, A. Chen, J.S. Ziegenfuss, W.B. Grueber, J.C. Canman, M.M. Shirasu-Hiza. 2017. A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells. The Journal of Cell Biology. 216(3): 595-605. doi: 10.1083/jcb.201607093. *Authors contributed equally. 

T. Davies*, S. Sundaramoorthy*, S.N. Jordan, M. Shirasu-Hiza, J. Dumont, J.C. Canman. 2017. Chapter 17 - Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans, In: Arnaud Echard, Editor(s), Methods in Cell Biology, Academic Press, Volume 137, Pages 283-306. doi: 10.1016/bs.mcb.2016.05.004. *Authors contributed equally. [PDF]

M. Ulgherait, A. Chen, M.K. Oliva, H.X. Kim, J.C. Canman, W.W. Ja, M. Shirasu-Hiza. 2016. Dietary restriction extends the lifespan of circadian mutants tim and per. Cell Metabolism. 24(6):763-4. doi: 10.1016/j.cmet.2016.11.002 [PDF]

S.N. Jordan, T. Davies, Y. Zhuravlev, J. Dumont, M. Shirasu-Hiza, J.C. Canman. 2016. Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division. The Journal of Cell Biology. 212(1):39-49. doi: 10.1083/jcb.201510063. [PDF]

T. Davies, S.N. Jordan and J.C. Canman. 2016. Cell polarity is on PAR with cytokinesis. Cell Cycle. 15(10):1307-1308. 

V.W. Allen, R.M. O'Connor, M. Ulgherait, C.G. Zhou, E.F. Stone, V.M. Hill, K.R. Murphy, J.C. Canman, W.W. Ja, M.M. Shirasu-Hiza. 2016. period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Current Biology. 26(2):184-94. doi: 10.1016/j.cub.2015.11.051.

G. Maton, F. Edwards, B. Lacroix, M. Stefanutti, K. Laband, T. Lieury, T. Kim, J. Espeut, J.C. Canman, J. Dumont. 2015. Kinetochore components are required for central spindle assembly. Nature Cell Biology. 17(5):697-705. doi: 10.1038/ncb3150 [PDF]

T. Davies*, S.N. Jordan*, V. Chand, J.A. Sees, K. Laband, A.X. Carvalho, M. Shirasu-Hiza, D.R. Kovar, J. Dumont, J.C. Canman. 2014. High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis. Developmental Cell. 30(2):209-23. doi: 10.1016/j.devcel.2014.05.009. *Authors contributed equally. [PDF]

S.N. Jordan and J.C. Canman. 2012. Rho GTPases in animal cell cytokinesis: An occupation by the one percent. Cytoskeleton. 69(11):919-30.

T. Davies and J.C. Canman. 2012. Stuck in the middle: Rac, Adhesion, and Cytokinesis. The Journal of Cell Biology. 198(5):769-71. 

S.N. Jordan, S. Olson, and J.C. Canman. 2011. Cytokinesis: Thinking outside of the cell. Current Biology. 21(3):R119 - R121. 

Julie C. Canman's Previously Published Work (prior to 2010)

J.C. Canman. 2009. Cytokinetic Astralogy. The Journal of Cell Biology. 187(6):757-759.

J.C. Canman, L. Lewellyn, S.J. Smerdon, K. Laband, A. Desai, B. Bowerman, and K. Oegema. 2008. Inhibition of Rac by the GAP Activity of Centralspindlin is Essential for Cytokinesis. Science. 322:1543-1546. 

M B. Goulding, J.C. Canman, E.N. Senning, A.H. Marcus, and B. Bowerman. 2007. Control of nuclear centration in the C. eleganszygote by receptor-independent Gα signaling and myosin II. The Journal of Cell Biology. 178:1177-91.

J.C. Canman. 2005. Becoming a Cell Voyeur. Nature Cell Biology. 7(8):783. 

J.C. Canman and W. A. Wells. 2004. Rappaport furrows on our minds: the ASCB Cytokinesis Meeting Burlington, VT July 22-25, 2004. The Journal of Cell Biology.166(7):943-8. (REVIEW ARTICLE)

L. Cameron, G. Yang, D. Cimini, J.C. Canman, O. Kisurina-Evgenieva, A. Khodjakov, G. Danuser, E.D. Salmon. 2006.  Kinesin 5-independent poleward flux of kinetochore microtubules in PtK1 cells. The Journal of Cell Biology. 173:173-179. (Faculty of 1000 score 6)

K.B. Shannon, J.C. Canman, C.B. Moree, J.S. Tirnauer, and E.D. Salmon. 2005. Taxol-stabilized microtubules can position the cytokinetic furrow in mammalian cells.  Molecular Biology of the Cell. 16((9):4423-4436.

DeAntoni, C.G. Pearson, D. Cimini, J.C. Canman, V. Sala, L. Nezi, M. Mapelli, L. Sironi, M. Faretta, E.D. Salmon, and A. Musacchio.2005. The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint. Current Biology. 15(3):214-225. 

R. Cheeks, J.C. Canman, W.N. Gabriel, N. Meyer, S. Strome, and B. Goldstein. 2004.  C. elegans PAR proteins drive the motility and asymmetric stabilization of polarized protein complexes. Current Biology. 14(10): 851-862.

J. DeLuca*, B. Howell*, J.C. Canman, J.M. Hickey, G. Fang, and E.D. Salmon. 2003. hNuf2 and Hec1 are required for retention, but not recruitment, of the checkpoint proteins Mad2 and Mad1 to kinetochores. Current Biology. 13(23):2103-2109. *Authors contributed equally. 

D. Cimini, B. Moree, J.C. Canman, and E.D. Salmon. 2003. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. Journal of Cell Science. 116: 4213-4225. 

J.C. Canman, L. Cameron, P. Maddox, A. Straight, J.S. Tirnauer, G. Fang, T.J. Mitchison, T. Kapoor, and E.D. Salmon. 2003. Determining the Cell Division Plane. Nature. 424:1074-1078. 

J.S. Tirnauer, J.C. Canman, E.D. Salmon, and T.J. Mitchison. 2002. EB1 Targets to kinetochores with attached, polymerizing microtubules. Molecular Biology of the Cell. 13(12):4308-16. 

J.C. Canman, E.D. Salmon, and G. Fang. 2002. Inducing Precocious Anaphase in Cultured Mammalian Cells. Cell Motility and the Cytoskeleton. 52:61-65.

P. Maddox, B. Moree, J.C. Canman, and E.D. Salmon. 2002. A spinning disk confocal microscope system for rapid high resolution, multimode, fluorescent speckle microscopy and GFP imaging in living cells. Methods in Enzymology. 360:597-617.

K. Shannon, J.C. Canman, and E.D. Salmon. 2002. Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension. Molecular Biology of the Cell. 13(10):3706-19. 

J.C. Canman, N. Sharma, A. Straight, K. Shannon, G. Fang, and E.D. Salmon. 2002. Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins. The Journal of Cell Science.115(19):3787-95.

B.J. Howell, B.F. McEwen* J.C. Canman*, D.B. Hoffman, E.M. Farrar, C.L. Rieder, and E.D. Salmon. 2001. Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation. Journal of Cell Biology. 155(7):1159-1172. *Authors contributed equally. 

J.L. Sumerel, J.C. Moore, B.J. Schnackenberg, J.A. Nichols, J.C. Canman, G.M. Wessel, and W.F. Marzluff. 2001. Cyclin E and its associated cdk activity do not cycle during early embryogenesis of the sea urchin. Developmental Biology. 234(2):425-440.

Y. Xue, J.C. Canman, C.S. Lee, Z. Nie, D. Yang, G.T. Moreno, M.K. Young, E.D. Salmon, and W. Wang. 2000. The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes. Proceedings of the National Academy of Sciences. 97:13015-13020.

J.C. Canman, D. Hoffman, and E. D. Salmon. 2000. The role of pre- and post-anaphase microtubules in the cytokinetic phase, or C-phase, of the cell cycle. Current Biology. 10:611-614.

E.D. Salmon and J.C. Canman. 1998. Proper alignment and adjustment of the light microscope.  Current Protocols in Cell Biology.1:4.1.1-4.1.26. (Note, also published in Current Protocols in Immunology. 2002. 48:21.1.1-21.1.26 and in Current Protocols in Human Genetics 2003 Appendix 3:Appendix 3N)

J.C. Canman and W.M. Bement. 1997. Microtubules suppress cortical flow in Xenopus laevis oocytes. Journal of Cell Science.110:1907-1917.